I cloned an IDE 2.5" hard drive here, however it only works in PIO mode.

I tried removing the drivers for IDE device and rebooted system but that did not work?

Any ideas anyone?

You've given almost nothing to work with here, but you might check out the multiple tips offered here:
http://winhlp.com/node/10

btw, I recommend this program for very easily examining your system, software, driver, and device status and settings. A lot easier and faster than using cmoparable system panels and better organized, too. Supports thru Win7. Free and paid(Pro) versions available.
http://www.majorgeeks.com/SIW_System_Info_d4387.html
http://www.gtopala.net/